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refrigeradores criogénicos para processos químicos de fluxo de medicamentos
Low temperature chillers used in drug flow chemistry (continuous manufacturing) processes are one of the key equipment to ensure that reactions occur under precise temperature conditions. Flow Chemistry is a continuous manufacturing technology that achieves chemical reactions through microchannels in flow reactors, with the advantages of high efficiency, controllability, and scalability.
The role of low-temperature chillers in drug flow chemistry
- Controlo preciso da temperatura:
Flow chemistry reactions often require strict temperature conditions to ensure selectivity and yield of the reaction.
Low temperature chillers can provide precise temperature control, typically with an accuracy of ± 0.1 ° C or less, ensuring that reactions occur within the desired temperature range.
- Improve reaction efficiency:
Under low temperature conditions, the speed and selectivity of certain chemical reactions will significantly increase.
Low temperature chillers can help maintain a low-temperature environment, accelerate reaction processes, and improve production efficiency.
- Prevent side reactions:
Many chemical reactions are prone to producing by-products or unwanted side reactions at high temperatures.
Low temperature chillers can effectively prevent side reactions and improve product purity by maintaining a low temperature environment.
- Enhance security:
Some chemical reactions may become unstable or dangerous at high temperatures.
Low temperature chillers can reduce safety hazards and improve production safety by lowering the reaction temperature.
- Improve repeatability and scalability:
An important advantage of flow chemistry is its repeatability and scalability.
Low temperature chillers help achieve reproducibility and consistency in large-scale production by providing stable temperature conditions.
Technical characteristics of low-temperature chiller
- Cooling capacity:
According to specific application requirements, choose the appropriate cooling capacity, usually ranging from several kilowatts to tens of kilowatts.
For applications that require extremely low temperatures, a chiller with stronger cooling capacity can be chosen.
- Gama de temperaturas:
Low temperature chillers can typically provide a temperature range from room temperature to -80 ° C or even lower.
Choose a chiller that can cover the desired temperature range to accommodate different chemical reaction requirements.
- Circulating pump:
The circulation pump circulates the cooling medium (such as water or ethylene glycol solution) between the chiller and the reactor to ensure uniform temperature distribution.
The flow rate and head should be selected according to the resistance and demand of the system.
- Control system:
PID controller: Achieve high-precision temperature control.
Temperature sensor: installed at a critical position of the cooling medium to monitor temperature in real-time User interface: Touch screen or digital display screen, convenient for setting and monitoring temperature.
- Dispositivo de proteção de segurança:
- Over temperature protection: When the temperature exceeds the set value, the power will be automatically cut off.
Overvoltage protection: prevents excessive system pressure Leakage detection: Check whether the system has leaks
situation.
Emergency stop button: Quickly stop system operation in case of emergency.
Exemplos de aplicação
- Low temperature synthesis reaction:
When synthesizing certain drug intermediates or active ingredients, reactions need to be carried out under low-temperature conditions.
Low temperature chillers can provide a stable low-temperature environment to ensure the smooth progress of reactions.
- Processo de cristalização:
Accurate temperature control is crucial for the formation of the desired crystal morphology during the crystallization process.
Low temperature chillers can help achieve the desired crystallization temperature and improve the quality of crystallized products.
- Enzyme catalyzed reaction:
In enzyme catalyzed reactions, enzyme activity is usually higher at low temperatures.
Low temperature chillers can maintain a suitable temperature and improve the catalytic efficiency of enzymes.
- Post reaction processing:
After the reaction is complete, it may be necessary to separate and purify the product under low temperature conditions.
The low-temperature chiller can provide the required low-temperature environment to ensure the smooth progress of the post-treatment process.
Low temperature chillers used in drug flow chemistry (continuous manufacturing) processes are key equipment to ensure that reactions occur under precise temperature conditions. By providing a stable low-temperature environment, reaction efficiency can be improved, side reactions can be prevented, safety can be enhanced, and product purity can be improved. When choosing a low-temperature chiller, factors such as temperature range, refrigeration capacity, flow and pressure, temperature control accuracy, and safety protection should be comprehensively considered to ensure that the chiller can meet specific application needs.
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